[Gozzie]

misfire can on any cylinder and can be from many sources. Let us know what you have already done.
spark plug
plug wire
coil
injector
Are you getting any noises ? Any other codes ?

 

[Gozzie]

sure, any lifter can go bad. Is it constant or intermittent ? I think they are usually accompanied with some noise from not pumping up correctly but not sure.
Read this, it may help you out more http://www.random-misfire.com/