I would suspect one of the little plastic clips that holds the rod on the door latch or on the pull handle has broken. You'll have to pull the door panel to verify.

 

I'll do that and let you know, I just watched a video on replacing the cable and they mentioned those clips your referring to. I thought it might be the little ball at the end of the cable but I'll know for sure when I get the door panel off. Thanks for the info.

 

If it is an 07+ model and looks like mine, then it will be a cable for the inside handle. Like Gary mentioned, best to pull the door panel and find out what happened then order parts if needed. You could need an inside door handle itself if the plastic that holds the ball end on the cable broke.

My experience is on the SLT trim handle vs the standard truck trim handle though.

 

Might be the clip has come unhooked

 

@St3v3 , you need to clarify which truck you have, a '07 classic or an 07.5. The setup is different between the two models.

 

I had my handles fail to open the door once, couldn't get out of the truck. Drove home, pulled up to the house, my wife opened the door and it never malfunctioned again!